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Functional polymorphisms in microRNA gene and hepatitis B risk among Asian population: a meta-analysis

G Q Zhou1, H Meng2, J R Wang2

  • 1Center of Integrated Traditional Chinese and Western Medicine, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing, China guiqin_zhou@126.com.

Genetics and Molecular Research : GMR
|May 13, 2015
PubMed

Insights

Certain microRNA gene mutations increase hepatitis B risk in Asians, specifically miR-196a-2, miR-122, miR-106b-25, and miR-let-7c. Other microRNA polymorphisms showed no significant link to hepatitis B susceptibility.

Area of Science:

  • Genetics
  • Molecular Biology
  • Hepatology

Background:

  • MicroRNA (miRNA) gene mutations can alter gene expression, potentially increasing disease risk.
  • The association between miRNA gene polymorphisms and hepatitis B virus (HBV) infection risk is not well-established, with existing studies yielding inconclusive results.

Purpose of the Study:

  • To conduct a comprehensive review and meta-analysis to precisely estimate the association between polymorphisms in miRNA genes and the risk of developing hepatitis B.
  • To identify specific miRNA gene variations that may influence hepatitis B susceptibility, particularly in the Asian population.

Main Methods:

  • A systematic digital search of MEDLINE, EMBASE, CNKI, and CBM databases was conducted for relevant studies published up to February 18, 2014.
  • Ten case-control studies comprising 6042 hepatitis B patients and 6834 healthy controls were included in the meta-analysis.
  • Nine single-nucleotide polymorphisms (SNPs) in miRNA genes were analyzed: miR-34b/c, miR-196a-2, miR-146a, miR-499, miR-122, miR-149, miR-106b-25, miR-let-7c, and miR-218.

Main Results:

  • The meta-analysis identified that specific alleles/carriers of miR-196a-2*T, miR-122*del, miR-106b-25*A, and miR-let-7c*del significantly increase the risk of hepatitis B in the Asian population.
  • Conversely, polymorphisms in miR-146a, miR-499, miR-149, miR-218, and miR-34b/c were not found to be significantly associated with hepatitis B risk.
  • The findings suggest a population-specific genetic influence of certain miRNA polymorphisms on hepatitis B susceptibility.

Conclusions:

  • Specific microRNA gene polymorphisms, including miR-196a-2, miR-122, miR-106b-25, and miR-let-7c, are associated with an increased risk of hepatitis B in the Asian population.
  • Polymorphisms in miR-146a, miR-499, miR-149, miR-218, and miR-34b/c do not appear to be linked to hepatitis B risk.
  • Further research is necessary to elucidate the precise mechanisms underlying the association between microRNA gene mutations and hepatitis B susceptibility.

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