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Optical paper-based sensor for ascorbic acid quantification using silver nanoparticles.

Danielle Cristhina Melo Ferreira1, Gabriela Furlan Giordano1, Caio César dos Santos Penteado Soares1

  • 1LNNano - Laboratório Nacional de Nanotecnologia, Centro Nacional de Pesquisa em Energia e Materiais, CEP 13083-970, Campinas, São Paulo, Brazil.

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Summary
This summary is machine-generated.

This study introduces a novel paper-based sensor using silver nanoparticles (AgNPs) for rapid, colorimetric quantification of ascorbic acid (AA). The sensor offers accurate, point-of-care detection comparable to lab methods.

Keywords:
Ascorbic acid detectionColorimetric analysisPaper-based deviceSensorSilver nanoparticles

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Area of Science:

  • Nanomaterials Science
  • Analytical Chemistry
  • Biomedical Engineering

Background:

  • Ascorbic acid (AA) is a vital nutrient with numerous health implications.
  • Accurate and accessible quantification of AA is crucial for health monitoring.
  • Existing analytical methods can be time-consuming and require specialized equipment.

Purpose of the Study:

  • To develop and validate a novel paper-based sensor for rapid, colorimetric quantification of ascorbic acid.
  • To demonstrate the utility of silver nanoparticles (AgNPs) in a portable sensing platform.
  • To evaluate the sensor's performance for point-of-care applications.

Main Methods:

  • Fabrication of a paper-based sensor incorporating AgNPs and silver ions within a hydrophobic barrier.
  • Colorimetric analysis of ascorbic acid concentrations based on AgNP color changes (yellow to gray).
  • Quantification using a scanner or a portable transmittance colorimeter.

Main Results:

  • The developed sensor enabled quantitative and fast analysis of ascorbic acid.
  • Color intensity changes correlated with ascorbic acid concentration.
  • Achieved a limit of detection comparable to laboratory-based methods.
  • Demonstrated sensitivity similar to standard titration methods in real samples.

Conclusions:

  • The AgNPs paper-based sensor is a promising tool for point-of-care ascorbic acid monitoring.
  • This method offers a cost-effective, rapid, and accurate alternative to conventional analytical techniques.
  • The sensor's performance validates its potential for widespread use in clinical and field settings.