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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Drug Dosing: Geriatric Patients01:15

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Updated: Apr 12, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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[Transfusions in geriatrics].

Sophie Moulias, Christine Lesure

    Soins. Gerontologie
    |May 14, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Elderly individuals often require red blood cell transfusions due to anemia. New guidelines emphasize a case-by-case risk-benefit analysis for transfusions, especially in chronic anemia cases, due to adverse effects.

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    Area of Science:

    • Geriatric Medicine
    • Hematology

    Context:

    • Elderly populations are highly susceptible to anemia.
    • Anemia in older adults frequently necessitates red blood cell transfusions.
    • Chronic anemia presents unique challenges in transfusion management.

    Purpose:

    • To review new recommendations regarding red blood cell transfusions in the elderly.
    • To highlight the risks associated with blood transfusions.
    • To advocate for individualized patient assessment.

    Summary:

    • New guidelines address red blood cell transfusions in elderly patients with anemia.
    • Adverse effects of transfusions are a key consideration.
    • A case-by-case risk-benefit analysis is crucial for determining transfusion necessity.

    Impact:

    • Informs clinical practice for managing anemia in elderly patients.
    • Promotes safer transfusion strategies.
    • Encourages personalized medicine approaches in geriatric hematology.