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First Experience of Concomitant Vaccination Against Dengue and MMR in Toddlers

Denis Crevat1, Job D Brion, Sophia Gailhardou

  • 1From the *Clinical Department, Sanofi Pasteur, Marcy l'Etoile, France; †San Pablo City Health Office, San Pablo, Philippines; ‡Pharmacovigilance Department, Sanofi Pasteur, Lyon, France; §Clinical Department, Sanofi Pasteur, Makati, Philippines; and ¶Research Institute for Tropical Medicine, Muntinlupa City, Philippines.

The Pediatric Infectious Disease Journal
|May 14, 2015
PubMed

Insights

This study shows the recombinant dengue vaccine (CYD-TDV) is safe and effective in toddlers. Coadministration with the measles, mumps, and rubella (MMR) vaccine did not impact its immunogenicity.

Area of Science:

  • Tropical Medicine
  • Vaccinology
  • Pediatric Infectious Diseases

Background:

  • Dengue poses a significant public health threat to children in dengue-endemic areas.
  • A recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TDV) is being developed for dengue control.
  • The vaccine is administered on a 3-dose schedule (0-6-12 months).

Purpose of the Study:

  • To evaluate the safety and immunogenicity of the CYD-TDV in toddlers.
  • To assess the effects of coadministering CYD-TDV with the measles, mumps, and rubella (MMR) vaccine.

Main Methods:

  • A controlled phase II trial in 210 toddlers (12-15 months) in the Philippines.
  • Participants received CYD-TDV with MMR concomitantly or 1 month prior, or received active control vaccines.
  • Safety, reactogenicity, and immunogenicity (dengue and MMR) were assessed post-vaccination.

Main Results:

  • CYD-TDV demonstrated an acceptable safety profile with no major safety concerns.
  • Fever was more frequent with CYD-TDV and MMR coadministration but reactogenicity did not increase with subsequent doses.
  • The vaccine induced a balanced antibody response to all four dengue serotypes and did not affect MMR immunogenicity.

Conclusions:

  • The CYD-TDV vaccine is safe and immunogenic in toddlers.
  • Coadministration with the MMR vaccine is feasible and does not compromise the immunogenicity of either vaccine.
Abstract

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