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Updated: Apr 12, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
[Therapeutic vaccines is a novel approach in castration-resistant prostate cancer treatment]
Sissal Sigmundsdòttir Djurhuus1, Klaus Brasso, Kasper Drimer Berg
1Copenhagen Prostate Cancer Center, Rigshospitalet, Tagensvej 20, 2200 København N. andreasroder@gmail.com.
Abstract:
Castration-resistant prostate cancer (CRPC) is defined as tumour progression despite castrate levels of serum testosterone. During the past decade a number of new therapies, including chemotherapy and novel endocrine agents have been approved for CRPC treatment. The continued need for new effective drugs in CRPC has led to development of a novel therapeutic approach in CRPC treatment. Therapeutic vaccines activate the immune system to kill prostate cancer cells. This review describes recent pivotal phase 2 and 3 trials of CRPC vaccines and discusses the impact on future CRPC management.
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