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Dexamethasone-induced withdrawal seizure.
Santwana Mahar1, Mahima Malhotra2
1Department of Pharmacology, NDMC Medical College, Hindu Rao Hospital, Delhi, India.
Journal of Pharmacology & Pharmacotherapeutics
|May 14, 2015
Summary
Dexamethasone withdrawal can rarely cause seizures. This study highlights steroid discontinuation as a potential trigger for this uncommon seizure phenomenon.
Area of Science:
- Neurology
- Pharmacology
Background:
- Steroid therapy, including dexamethasone, is sometimes used for weight gain.
- Discontinuation of corticosteroids can lead to withdrawal symptoms.
Observation:
- A rare case of seizure occurred after stopping dexamethasone therapy.
- The patient had been taking steroids to increase weight.
Findings:
- Steroid withdrawal, specifically dexamethasone, can precipitate seizures.
- This represents an uncommon withdrawal phenomenon.
Implications:
- Clinicians should be aware of seizure risk during steroid withdrawal.
- Further research is needed to understand the underlying pathophysiology of steroid-induced withdrawal seizures.
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