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Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
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Published on: September 16, 2011

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Hypersensitivity reaction with deferasirox

Atul Sharma1, Ekta Arora2, Harmanjit Singh2

  • 1Department of Medicine, Smt. Sucheta Kriplani Hospital and Lady Hardinge Medical College (LHMC), New Delhi, India.

Journal of Pharmacology & Pharmacotherapeutics
|May 14, 2015
PubMed

Thalassemias comprise a group of hereditary blood disorders. Thalassemia major presents with anemia within the first 2 years of life requiring frequent blood transfusions for sustaining life. Regular blood transfusions lead to iron overload-related complications. Prognosis of thalassemia has improved because of the availability of iron-chelating agents. Oral iron chelators are the mainstay of chelation therapy. Deferasirox is a new-generation oral iron chelator for once daily usage. We herein describe a patient of beta thalassemia major who developed an allergic manifestation in the form of erythematous pruritic skin rashes to the oral iron chelator deferasirox. This is a rare adverse reaction reported with deferasirox that led to a therapeutic dilemma in this particular case.

Keywords:
Deferasiroxrashthalassemia

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