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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
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Coherent regulation in yeast's cell-cycle network.

Neşe Aral1, Alkan Kabakçıoğlu

  • 1Department of Physics, Koç University, Rumelifeneri Yolu Sarıyer 34450, Istanbul, Turkey.

Physical Biology
|May 14, 2015
PubMed
Summary

Gene regulatory networks exhibit high coherent activity, suggesting evolutionary selection for energy efficiency. Yeast cell-cycle regulation demonstrates exceptionally coordinated gene control, optimizing cellular function.

Area of Science:

  • Systems biology
  • Computational biology
  • Genetics

Background:

  • Gene regulatory networks (GRNs) control cellular functions through complex interactions.
  • Energy efficiency is a critical factor influencing biological system design and evolution.
  • Understanding network properties can reveal underlying biological principles.

Purpose of the Study:

  • To define and quantify coherent activity in gene regulatory networks.
  • To investigate the relationship between coherent activity, energy efficiency, and evolutionary pressures.
  • To analyze the cell-cycle regulatory network of Saccharomyces cerevisiae as a model system.

Main Methods:

  • Development of a novel measure for coherent activity in GRNs.
  • Application of the coherence measure to two models of the yeast cell-cycle GRN.

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  • Comparison of coherence levels in biological networks versus random networks.
  • Analysis of coherence as a function of network size, connectivity, and interaction types.

    • Main Results:

    • Yeast cell-cycle regulation exhibits an exceptionally high degree of coherent activity.
    • Coherence in yeast GRNs significantly exceeds that of random networks of comparable characteristics.
    • The study identified key network features contributing to high coherence.

    Conclusions:

    • Coherent regulatory activity is a significant property of biological networks, potentially driven by evolutionary selection for energy efficiency.
    • The yeast cell-cycle network is highly optimized for coordinated gene regulation.
    • Further research can explore coherence in other biological systems and its functional implications.