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Leg cramps.

Gavin Young1

  • 1Temple Sowerby Medical Practice, Penrith, UK.

BMJ Clinical Evidence
|May 14, 2015
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Summary
This summary is machine-generated.

This systematic review examines treatments for common leg cramps. Evidence on the effectiveness and safety of various interventions, including medications and exercises, is presented.

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Area of Science:

  • Neurology
  • Evidence-Based Medicine

Background:

  • Involuntary, localized leg cramps, particularly affecting calf muscles at night, are a common condition.
  • Idiopathic leg cramps and leg cramps during pregnancy are distinct clinical scenarios requiring specific treatment considerations.

Purpose of the Study:

  • To systematically review the effects of various treatments for idiopathic leg cramps.
  • To evaluate the effects of treatments for leg cramps occurring during pregnancy.

Main Methods:

  • A comprehensive systematic review was conducted, searching major databases including Medline, Embase, and The Cochrane Library up to January 2014.
  • Included studies underwent a GRADE evaluation to assess the quality of evidence for different interventions.
  • Harms alerts from regulatory agencies like the FDA and MHRA were also incorporated.

Main Results:

  • Sixteen studies met the inclusion criteria for the review.
  • The review assessed the quality of evidence for numerous interventions using the GRADE system.

Conclusions:

  • The systematic review provides information on the effectiveness and safety of a wide range of interventions.
  • Interventions evaluated include analgesics, anti-epileptic drugs, calcium salts, diltiazem, magnesium salts, multivitamin and mineral supplements, quinine, sodium chloride, stretching exercises, verapamil, vitamin B6 (pyridoxine), and vitamin E.