Related Experiment Video
Updated: Apr 12, 2026

Author Spotlight: Quantifying Siderophores and Pyochelin for Infection Control
Published on: March 15, 2024
Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategy
1Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA.
Abstract:
The rise of antibiotic resistance is a growing public health crisis. Novel antimicrobials are sought, preferably developing nontraditional chemical scaffolds that do not inhibit standard targets such as cell wall synthesis or the ribosome. Iron scavenging has been proposed as a viable target, because bacterial and fungal pathogens must overcome the nutritional immunity of the host to be virulent. This review highlights the recent work toward exploiting the biosynthetic enzymes of siderophore production for the design of next generation antimicrobials.
Related Concept Videos
Antimicrobial Proteins
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Inhibitors of Bacterial Protein Synthesis
Gene Regulation in Microbial Communities: Quorum Sensing
Clinical Significance of Antibiotic Resistance
Biological Methods for Microbial Control
Production of Antibiotics

