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A High-throughput Automated Platform for the Development of Manufacturing Cell Lines for Protein Therapeutics
Published on: September 22, 2011
22.9K
Cell line development for biomanufacturing processes: recent advances and an outlook
Huong Le1, Nandita Vishwanathan, Nitya M Jacob
1Amgen Inc., Thousand Oaks, USA.
Biotechnology Letters
|May 15, 2015
Summary
Advances in cell line development enhance recombinant protein production and quality. New genomic tools and genome editing are crucial for biosimilar manufacturing and achieving specific product attributes.
Area of Science:
- Biotechnology
- Biopharmaceutical Manufacturing
- Cell Line Development
Background:
- The production cell line is fundamental to recombinant protein biomanufacturing, impacting productivity and product quality.
- Cell line characteristics significantly influence bioprocess development and optimization strategies.
- Past decade advancements in vector design and screening have improved the generation of cell lines with desired traits.
Purpose of the Study:
- To review recent advancements in cell line development for recombinant protein production.
- To discuss the impact of new technologies on cell line engineering.
- To explore future possibilities, particularly for biosimilar manufacturing.
Main Methods:
- Review of recent literature on cell line development technologies.
- Analysis of the role of genomic and transcriptomic resources.
- Discussion of genome editing technologies in cell line engineering.
Main Results:
- Significant progress has been made in developing cell lines with specific desired traits.
- Increased availability of genomic and transcriptomic data aids cell line development.
- Genome editing technologies offer new avenues for precise cell line engineering.
Conclusions:
- Modern cell line development strategies are enhancing biomanufacturing capabilities.
- Technological advancements are critical for meeting the demands of biosimilar production.
- Future cell line development will likely leverage integrated genomic and editing approaches for targeted attribute control.
