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Insulin resistance using HOMA model in obstructive sleep apnea: a cross sectional study
Mawaddah Azman1, Abdullah Sani, Nor Azmi Kamaruddin
1Mawaddah Azman, MD, Department of Otolaryngology, National University of Malaysia,, Level 9, Clinical Block, Universiti Kebangsaan Malaysia Medical Centre,, Jalan Yaacob Latiff, 52000 Bandar Tun Razak,, Cheras, Kuala Lumpur 52000, Malaysia, T: +60391456045, F: +60391456675, mawaddah1504@yahoo.com.
Annals of Saudi Medicine
|May 15, 2015
Summary
Obstructive sleep apnea (OSA) is linked to insulin resistance (IR). Key OSA indicators like apnea-hypopnea index and waist circumference correlate with IR, suggesting a causal relationship and the need for IR screening in severe OSA cases.
Area of Science:
- Sleep Medicine
- Endocrinology
- Metabolic Syndrome
Background:
- Obstructive sleep apnea (OSA) is prevalent in middle-aged individuals.
- OSA is associated with cardiovascular, cerebrovascular, and metabolic complications.
- The link between OSA and insulin resistance (IR) remains inconclusive.
Purpose of the Study:
- To investigate the correlation between OSA parameters and IR.
- To determine if OSA severity influences IR.
- To explore potential causal links between OSA and metabolic dysfunction.
Main Methods:
- Cross-sectional study involving 62 patients undergoing polysomnography (PSG).
- Measured OSA parameters (apnea-hypopnea index, Epworth Sleepiness Scale - ESS), BMI, neck, and waist circumference (WC).
- Assessed IR using the Homeostasis Model Assessment (HOMA-IR) from fasting blood samples.
Main Results:
- Prevalence of IR was 64.3% in OSA patients.
- Significant positive correlations found between HOMA-IR and apnea-hypopnea index (r=0.529), ESS (r=0.224), BMI (r=0.261), and WC (r=0.354).
- These findings indicate a linear relationship between OSA severity and IR.
Conclusions:
- A definite causal link exists between OSA parameters and IR.
- IR screening is recommended for patients with severe OSA.
- Early detection and management of IR in OSA patients may mitigate associated health risks.
