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Updated: Apr 12, 2026

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes
Published on: March 9, 2019
A reconfigurable on-line learning spiking neuromorphic processor comprising 256 neurons and 128K synapses
Ning Qiao1, Hesham Mostafa1, Federico Corradi1
1Institute of Neuroinformatics, University of Zurich and ETH Zurich Zurich, Switzerland.
Researchers developed a novel neuromorphic chip with 128K analog synapses and 256 neurons. This compact, low-power system enables real-time, on-line learning for brain-inspired computing and artificial neural processing systems.
Area of Science:
- Neuroscience
- Computer Engineering
- Artificial Intelligence
Background:
- Compact, low-power artificial neural processing systems with real-time on-line learning are a significant challenge.
- Neuromorphic engineering seeks to emulate biological neural systems for advanced computation.
Purpose of the Study:
- To present a full-custom mixed-signal VLSI device with neuromorphic learning circuits.
- To enable exploration of computational neuroscience models and construction of brain-inspired computing systems.
Main Methods:
- Designed a mixed-signal VLSI device with 128K analog synapses and 256 neuron circuits.
- Emulated biophysics of spiking neurons and dynamic synapses with short-term and long-term plasticity.
- Integrated asynchronous digital logic for network configuration and property setting.
Main Results:
- The device supports on-chip configuration of recurrent and deep networks with plasticity.
- Fabricated prototype (180 nm CMOS) occupies 51.4 mm² and consumes ~4 mW.
- Demonstrated biologically plausible dynamics and bi-stable spike-based plasticity for on-line learning.
Conclusions:
- The developed neuromorphic chip facilitates the realization of intelligent autonomous systems.
- The device supports cortical-like computational modules and on-line learning capabilities.
- This work advances the field of brain-inspired computing systems.
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