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Assays for Validating Histone Acetyltransferase Inhibitors
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Assays for Validating Histone Acetyltransferase Inhibitors

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Treatment of chronic kidney diseases with histone deacetylase inhibitors

Na Liu1, Shougang Zhuang2

  • 1Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine Shanghai, China.

Frontiers in Physiology
|May 15, 2015
PubMed

Insights

Histone deacetylase inhibitors (HDACis) show promise in treating chronic kidney diseases by reducing fibrosis and inflammation. These compounds offer potential therapeutic benefits across various nephropathies in pre-clinical studies.

Area of Science:

  • Molecular Biology
  • Nephrology
  • Pharmacology

Background:

  • Histone deacetylases (HDACs) regulate gene expression through protein deacetylation.
  • HDAC inhibition has shown potential in mitigating kidney damage in various disease models.

Purpose of the Study:

  • To review the therapeutic potential of HDAC inhibitors (HDACis) in pre-clinical models of chronic kidney diseases.
  • To summarize the anti-fibrotic, anti-inflammatory, and immunosuppressive effects of HDACis in kidney disease.

Main Methods:

  • Literature review of pre-clinical studies on HDAC inhibitors and chronic kidney diseases.
  • Analysis of reported outcomes in models of renal fibrogenesis, polycystic kidney disease, diabetes nephropathy, lupus nephritis, aristolochic acid nephropathy, and transplant nephropathy.

Main Results:

  • HDAC inhibition attenuated renal fibrogenesis in obstructed kidneys.
  • HDACis reduced cyst formation in polycystic kidney disease models.
  • Beneficial effects were observed in ameliorating renal lesions across multiple nephropathies.

Conclusions:

  • HDAC inhibitors demonstrate significant therapeutic potential for various chronic kidney diseases.
  • The anti-fibrosis, anti-inflammation, and immunosuppressive properties underpin the efficacy of HDACis.
  • Further investigation in pre-clinical models supports HDACis as a promising therapeutic strategy for kidney diseases.
Keywords:
chronic kidney diseaseshistone deacetylasesrenal fibroblastsrenal fibrosis

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