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Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish
Published on: July 16, 2012
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An update on Anti-inflammatory Compounds: A Review.
Ashwani Kumar Dhingra1, Bhawna Chopra, Rameshwar Dass
1Guru Gobind Singh College of Pharmacy, Near Guru Nanak Khalsa College, City Center Road, Yamuna Nagar-135001, Haryana, India. ashwani1683@gmail.com.
Summary
Inflammation, linked to cancer, requires new drugs that target inflammatory cytokines without disrupting homeostasis. This review highlights novel anti-inflammatory molecules and past research, stressing the urgent need for safe and effective treatments.
Area of Science:
- Biomedical Science
- Pharmacology
- Immunology
Background:
- Inflammation is a critical biological response to injury, essential for healing but implicated in cancer development.
- Current anti-inflammatory strategies include immune-selective derivatives, glucocorticoid receptor agonists, resolvins, protectins, and TNF inhibitors.
- Herbal medicines have historically provided compounds targeting inflammatory cytokines.
Purpose of the Study:
- To review emerging molecular strategies for combating inflammation.
- To consolidate findings from previous research on anti-inflammatory agents.
- To underscore the urgent need for novel, safe, and effective anti-inflammatory drugs.
Main Methods:
- Literature review of recent scientific publications.
- Analysis of studies on novel anti-inflammatory molecules.
- Examination of historical research on herbal anti-inflammatory agents.
Main Results:
- Identification of newer therapeutic molecules targeting inflammatory pathways.
- Reaffirmation of the role of inflammation in various cancers.
- Evidence supporting the efficacy of certain herbal compounds in modulating inflammation.
Conclusions:
- The development of new anti-inflammatory drugs is imperative due to the high prevalence of inflammatory conditions.
- Novel molecules offer promising therapeutic potential for managing inflammation.
- A safe and efficient drug is urgently needed to protect against inflammation and its associated pathologies.
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