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Morphological Aspect and iNOS and Bax Expression Modification in Bone Tissue Around Dental Implants Positioned Using
Vincenzo Luca Zizzari1, Davide Berardi, Francesca Congedi
1*Departments of Pharmacy †Medical, Oral, and Biotechnological Sciences, University "G. d'Annunzio", Chieti, Italy.
Background:
The aim of this work is to evaluate differences occurring in bone tissue around dental implants positioned using piezoelectric or conventional drill technique.
Methods:
Twenty-four implants were inserted bilaterally in the iliac crest of 6 sheep after site preparation through a piezoelectric instrument (Test) or after site preparation through conventional drill technique with rotary instruments (Control). Animals were randomly divided to be euthanized at 15 and 30 days post-intervention (p.i.); peri-implant bone samples were withdrawn and processed for histological analysis and immunohistochemical evaluation of iNOS and Bax expression.
Results:
Active remodeling phenomena in both Test and Control samples are showed at 15 days p.i., while at 30 days p.i., the overall organization of the peri-implant bone resembles native bone tissue. Immunohistochemical evaluation reveals a statistically significant increase of both iNOS and Bax expression at 15 days p.i. compared to samples obtained 30 days p.i. and to native bone. At both healing times, a higher but not statistically significant iNOS and Bax expression is recorded in samples from Control compared to Test Group.
Conclusion:
Even if the insertion protocol does not seem to significantly interfere with the long-term healing process, implant site preparation through the piezoelectric bone surgery technique may allow a reduction of peri-implant bone tissue inflammation and support a more rapid bone tissue healing phase.
