Related Experiment Video
Updated: Oct 14, 2026
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
Comparison of pachymetry measurements between the Alcon Wavelight EX500 and Sonogage Corneo-Gage plus platforms
Purpose:
To compare the agreement of intraoperative central corneal thickness (CCT) measurements of the Wavelight EX500 (Alcon Laboratories, Fort Worth, TX) that uses optical low coherence reflectometry to the Corneo-Gage Plus ultrasound pachymetry device (Sonogage, Cleveland, OH).
Methods:
In this retrospective study, 50 eyes of 26 patients undergoing LASIK were evaluated. Following LASIK flap creation, each eye was measured by both optical low coherence reflectometry and ultrasound pachymetry immediately prior to flap lifting and then again after flap lifting.
Results:
The mean CCT value before lifting the flap was 556.9 and 557.78 µm as measured by ultrasound pachymetry and optical low coherence reflectometry, respectively. After lifting the flap, the mean ultrasound pachymetry value was 440.96 µm and the mean optical low coherence reflectometry value was 441.7 µm. A two-sample Kolmogorov-Smirnov test demonstrated that the ultrasound pachymetry and the optical low coherence reflectometry distribution of measurements were the same. A Shapiro-Wilk test of normality could not be rejected. Bland-Altman plots showed strong agreement. The correlation between the two tests was 0.98 before flap lifting and 0.97 after flap lifting, both with a 95% confidence interval.
Conclusions:
The pachymetry measurements by the optical low coherence reflectometry correlated with those of the ultrasound pachymetry device. The Wavelight EX500 optical low coherence reflectometry may be used in place of the ultrasound pachymetry device for measuring CCT.
