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miRNA expression atlas in male rat
Keiichi Minami1, Takeki Uehara2, Yuji Morikawa2
1Exploratory Research Laboratories, Tsukuba Research Institute, Ono Pharmaceutical Co., Ltd. , 17-2 Wadai, Tsukuba-shi, Ibaraki 300-4247, Japan.
Scientific Data
|May 16, 2015
Summary
This study created a comprehensive rat miRNA atlas from 55 organs. This resource maps microRNA (miRNA) profiles in normal tissues, aiding understanding of circulating biomarkers for physiological and toxicological states.
Area of Science:
- Genomics
- Molecular Biology
- Biomarker Discovery
Background:
- MicroRNAs (miRNAs) are key regulators of gene expression.
- Circulating miRNAs show promise as tissue-specific biomarkers for various conditions.
- Understanding normal miRNA profiles is crucial for interpreting disease-related changes.
Purpose of the Study:
- To construct a comprehensive miRNA atlas for normal male rats.
- To profile miRNA expression across 55 distinct organs and tissues.
- To support the Toxicogenomics Informatics Project in Japan (TGP2).
Main Methods:
- Genome-wide miRNA expression analysis using miRNA arrays.
- Profiling of 55 organs and tissues from normal male rats.
- Data compilation from a single, standardized study.
Main Results:
- Detailed miRNA expression profiles for multiple rat organs and tissues.
- Identification of organ-specific miRNAs within the normal rat dataset.
- A comprehensive dataset of miRNA profiles from normal samples.
Conclusions:
- The generated rat miRNA atlas provides a valuable reference dataset.
- This atlas facilitates the study of miRNA roles in physiological and toxicological conditions.
- It enhances the understanding of circulating miRNA biomarkers.
