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An open science resource for establishing reliability and reproducibility in functional connectomics
Xi-Nian Zuo1, Jeffrey S Anderson2, Pierre Bellec3
1Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences , Chaoyang, Beijing 100101, China ; Faculty of Psychology, Southwest University , Beibei, Chongqing 400715, China.
Scientific Data
|May 16, 2015
Summary
Researchers are improving the reliability of functional neuroimaging biomarkers. The Consortium for Reliability and Reproducibility (CoRR) shares resting-state fMRI data to standardize methods for analyzing brain function.
Area of Science:
- Neuroscience
- Neuroimaging
- Biomarkers
Background:
- Identifying reliable functional imaging biomarkers for human brain function is challenging due to variability in data acquisition and analysis methods.
- Existing connectomics measures show moderate to high reliability, but generalization is limited by diverse experimental designs and analytical approaches.
Purpose of the Study:
- To establish test-retest reliability as a minimum standard for methods development in functional connectomics.
- To address the challenge of characterizing inter-individual differences in human brain function using neuroimaging.
Main Methods:
- The Consortium for Reliability and Reproducibility (CoRR) aggregated 1,629 resting-state fMRI (rfMRI) datasets from 18 international sites, totaling 5,093 scans.
- Data were openly shared via the International Data-sharing Neuroimaging Initiative (INDI) to facilitate reliability and reproducibility assessments.
- Diverse data acquisition procedures, experimental designs, and varying data quality were included to enable comprehensive analysis of artifacts like motion.
Main Results:
- The CoRR dataset provides a standardized resource for evaluating the reliability and reproducibility of functional connectomics methods.
- The shared data allow researchers to assess the impact of various factors, including motion artifacts, on inter-individual variation in brain function.
Conclusions:
- Establishing test-retest reliability is crucial for advancing functional neuroimaging biomarkers.
- The CoRR initiative and shared dataset are vital for promoting standardized and reproducible research in functional connectomics.
