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The pediatric template of brain perfusion
Brian B Avants1, Jeffrey T Duda1, Emily Kilroy2
1Department of Radiology, University of Pennsylvania , Philadelphia, Pennsylvania 19104, USA.
Scientific Data
|May 16, 2015
Summary
The Pediatric Template of Brain Perfusion (PTBP) offers a free neuroimaging resource for studying childhood brain development. This MRI-based dataset tracks brain structure, function, and perfusion to reveal maturation patterns and potential psychiatric risks.
Area of Science:
- Neuroscience
- Developmental Neuroscience
- Medical Imaging
Background:
- Magnetic resonance imaging (MRI) is crucial for understanding brain development, offering insights into healthy maturation and early identification of psychiatric disorders.
- Existing neuroimaging resources may not fully capture the multifaceted dynamics of brain development across structure, function, and perfusion.
- Adolescent brain development involves complex structural and functional changes, critical for cognitive and behavioral maturation.
Purpose of the Study:
- To introduce the Pediatric Template of Brain Perfusion (PTBP), a novel, free, and public neuroimaging resource.
- To accelerate research into childhood brain development using multimodal MRI data.
- To provide a comprehensive dataset for understanding neural patterns related to healthy maturation and psychiatric risk.
Main Methods:
- Utilized cross-sectional and longitudinal MRI scans from 120 children aged 7-18 years.
- Quantified multiple brain imaging modalities: cortex, white matter, resting-state functional connectivity, and brain perfusion using Arterial Spin Labeling (ASL).
- Developed the PTBP resource, integrating neuroimaging data with cognitive and environmental factors.
Main Results:
- Demonstrated the validity of the PTBP by showing that global summary measurements accurately capture developmental trajectories.
- Identified critical turning points in brain maturation through comprehensive analysis of structural and functional data.
- Established normative data for brain perfusion, structure, and functional connectivity in a pediatric cohort.
Conclusions:
- The PTBP is a valuable, publicly accessible resource for advancing the understanding of adolescent brain development.
- This dataset facilitates detailed investigation into network-level, structural, and functional landmarks of normal brain maturation.
- The PTBP has the potential to significantly contribute to early risk identification for psychiatric disorders in children and adolescents.
