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Updated: Apr 12, 2026
The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
Published on: October 7, 2016
Improved method for synthesis of cysteine modified hyaluronic acid for in situ hydrogel formation
Xin Zhang1, Pengcheng Sun, Lingzi Huangshan
1Key Laboratory of Tropical Biological Resources of Ministry of Education, College of Oceanography, Hainan University, Haikou, Hainan Province 570228, China. bhhu@hainu.edu.cn.
Abstract:
We developed a new strategy for the functionalization of hyaluronic acid by chemical modification of its C-6 hydroxyl groups through an ether bond to obtain a cysteine-hyaluronic acid conjugate. This conjugate is suitable to prepare injectable and in situ formed hydrogels cross-linked by native chemical ligation and Michael addition under mild conditions.
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