The occurrence of depression following mania. A method of predicting vulnerable cases

In a retrospective analysis of 100 cases of mania (1981-1985), the incidence of subsequent depression was found to be 30%. Its occurrence was significantly associated with three factors: cyclothymic pre-morbid personality, family history of affective disorder, and past history of depression. By discriminant analysis, outcome could be predicted successfully in 81% of cases.