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Thrombocytopaenia and neutropaenia associated with daptomycin USE

Fernando Leyra1, Nuria Perez-Chuliá1, Cristina Jofré1

  • 1a Anesthesiology Department , Hospital Universitario La Paz , Madrid , Spain.

Journal of Chemotherapy (Florence, Italy)
|May 16, 2015
PubMed

Insights

This study details a rare case of simultaneous thrombocytopaenia and neutropaenia in a patient undergoing prolonged daptomycin treatment for endocarditis, highlighting potential adverse effects of this antibiotic.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Hematology

Background:

  • Daptomycin is a lipopeptide antibiotic effective against Gram-positive bacteria, used for skin infections and Staphylococcus aureus bloodstream infections.
  • Product information lists thrombocytopaenia as a potential adverse effect, but not neutropaenia.
  • Previous literature includes two cases of daptomycin-induced thrombocytopaenia and one of neutropaenia with prolonged use.
Keywords:
CefepimeDaptomycinEndocarditisNeutropaeniaThrombocytopaenia

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