Neural tissue regeneration in experimental brain injury model with channeled scaffolds of acrylate copolymers
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Updated: Apr 12, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
Published on: May 31, 2017
Cristina Martínez-Ramos1, Ulises Gómez-Pinedo2, Maria Angeles Garcia Esparza3
1Centro de Biomateriales, Universitat Politècnica de València, P. O. Box 22012, E-46071 València, Spain.
Abstract:
The objective of the present study was to evaluate the biocompatibility and cell hosting ability of a copolymer scaffold based on ethyl acrylate (EA) and hydroxyl ethyl acrylate (HEA) in vivo after an experimental brain injury. Wistar rats were subjected to cryogenic traumatic brain injury. We evaluated the tissue response to the implanted materials after 8 weeks. The materials were implanted devoid of cells; they provoked a minimal scar response by the host tissue and permitted the invasion of neurons and glia inside them. We also found new blood vessels surrounding and inside the implant. Thus, the copolymer scaffold proves to offer a suitable environment producing a cellular network potentially useful in brain repair after brain injury.

