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Updated: Apr 12, 2026
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An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
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Perspectives On Membrane-associated Progesterone Receptors As Prospective Therapeutic Targets
Sae Hasegawa, Mayu Kasubuchi, Kazuya Terasawa
1Department of Applied Biological Science, Tokyo University of Agriculture and Technology Graduate School of Agriculture, Fuchu-shi, Tokyo 183-8509, Japan. ikimura@cc.tuat.ac.jp.
Current Drug Targets
|May 19, 2015
Summary
Membrane-associated progesterone receptors (MAPRs) mediate rapid, non-genomic progesterone effects, influencing cell growth. These MAPRs show promise as biomarkers and drug targets for hormone-related cancers.
Area of Science:
- Endocrinology
- Molecular Biology
- Cell Biology
Background:
- Membrane-associated progesterone receptors (MAPRs), including PR membrane components 1 and 2, neudesin, and neuferricin, are emerging as key players in rapid, non-genomic signaling.
- These receptors are distinct from classical nuclear progesterone receptors and mediate effects not explained by genomic actions.
Purpose of the Study:
- To review the physiological roles of MAPRs.
- To provide a comprehensive overview of progesterone-mediated non-genomic actions via MAPRs.
- To discuss the potential of MAPRs as therapeutic targets and biomarkers.
Main Methods:
- Literature review of studies on MAPRs and progesterone signaling.
- Analysis of non-genomic pathways activated by progesterone through MAPRs, such as MAPK and PI3K.
- Examination of MAPR expression patterns in relation to diseases.
Main Results:
- Progesterone binding to MAPRs can rapidly activate intracellular signaling pathways, including mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K).
- These non-genomic effects contribute to cellular processes like proliferation and survival.
- Unique expression profiles of MAPRs suggest their involvement in various physiological and pathological conditions.
Conclusions:
- MAPRs are critical mediators of progesterone's rapid non-genomic effects.
- MAPRs represent promising therapeutic targets and biomarkers for sex steroid-related cancers and other diseases.
- Further research into MAPR function and pharmacology is warranted.
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