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The role of the dynorphin/κ opioid receptor system in anxiety
Ai Hang1, Yu-jun Wang2, Ling He1
1Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China.
Abstract:
Anxiety disorders are the most common and prevalent forms of psychiatric disease, although the biological basis of anxiety is not well understood. The dynorphin/κ opioid receptor system is widely distributed in the central nervous system and has been shown to play a critical role in modulating mood and emotional behaviors. In the present review, we summarize current literature relating to the role played by the dynorphin/κ opioid receptor system in anxiety and κ opioid receptor antagonists as potential therapeutic agents for the treatment of anxiety disorders.
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