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Initial experience with therapeutic geometric modification of the carotid bulb for true resistant hypertension

Najibullah Habib1, Bakhtawar K Mahmoodi, Willem Jan W Bos

  • 1Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.

Eurointervention : Journal of Europcr in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
|May 19, 2015
PubMed

Insights

Carotid baroreceptor feedback

Area of Science:

  • Cardiovascular physiology
  • Hypertension research

Background:

  • Carotid baroreceptor feedback's role in essential hypertension is unclear.
  • Carotid sinus nerve potentials depend on bulb stretch and pulsatile pressure.
  • Baroreceptor feedback resets in hypertensive patients.

Observation:

  • A resistant hypertension patient received an intravascular prosthesis.
  • The prosthesis altered carotid bulb pulsatile strain patterns.

Findings:

  • The patient experienced a significant blood pressure reduction.
  • This suggests a link between altered pulsatile strain and blood pressure control.

Implications:

  • Modulating carotid bulb strain may offer new hypertension treatments.
  • Further research into baroreceptor mechanics is warranted.

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