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Related Concept Videos

Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

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DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
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Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
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Heart Failure III: Clinical Manifestations01:26

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Pathophysiology of Heart Failure01:17

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Related Experiment Video

Updated: Apr 12, 2026

A Murine Model of Hemodialysis Access-Related Hand Dysfunction
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Left ventricular dysfunction in the haemodialysis population.

Manish M Sood1, Robert P Pauly2, Claudio Rigatto1

  • 1St Boniface General Hospital and the University of Manitoba , Winnipeg, Manitoba , Canada.

NDT Plus
|May 19, 2015
PubMed
Summary
This summary is machine-generated.

Cardiovascular disease is a major concern for patients on hemodialysis, leading to increased mortality. Left ventricular dysfunction is common, but definitions and treatments remain challenging due to limited research.

Keywords:
beta blockerscardiac defibrillatorshaemodialysisleft ventricular dysfunctionnocturnal haemodialysis

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Area of Science:

  • Nephrology
  • Cardiology

Background:

  • Cardiovascular disease (CVD) significantly contributes to mortality and morbidity in the hemodialysis population.
  • Left ventricular dysfunction (LVDys), including geometric and functional disorders, is highly prevalent and linked to increased mortality in hemodialysis patients.
  • Hypertension, ischemic heart disease, and dilated cardiomyopathy are common causes of LVDys in this population.

Purpose of the Study:

  • To highlight the diagnostic and therapeutic challenges associated with left ventricular dysfunction in hemodialysis patients.
  • To review current understanding and potential future directions for managing CVD in this vulnerable group.

Main Methods:

  • Literature review focusing on the prevalence, definition, and management of left ventricular dysfunction in hemodialysis patients.
  • Discussion of diagnostic limitations, such as echocardiography's volume dependency.
  • Exploration of evidence from non-dialysis populations and emerging interventional therapies.

Main Results:

  • Left ventricular dysfunction is inadequately defined in current literature, complicating diagnosis and treatment.
  • Echocardiography screening can underestimate left ventricular ejection fraction due to volume status dependency.
  • Limited randomized controlled trials exist, necessitating extrapolation of data from non-dialysis populations.

Conclusions:

  • Standardizing the definition and improving diagnostic accuracy for LVDys in hemodialysis patients is crucial.
  • Interventional cardiac procedures like defibrillator implantation and cardiac resynchronization therapy show potential.
  • Exploring alternative dialysis modalities (peritoneal, short-daily, nocturnal) may offer therapeutic benefits for cardiovascular health.