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Cardiac manifestations in Behcet's disease

Selami Demirelli1, Husnu Degirmenci2, Sinan Inci3

  • 1Selami Demirelli, M.D, Department of Cardiology, Erzurum Education and Research Hospital, Erzurum, Turkey;

Intractable & Rare Diseases Research
|May 19, 2015
PubMed

Insights

Behcet's disease (BD) involves cardiovascular complications like cardiac lesions and arterial issues. Treatment focuses on managing vasculitis, with outcomes improving through anticoagulation, immunosuppression, and colchicine.

Area of Science:

  • Rheumatology
  • Cardiology
  • Immunology

Background:

  • Behcet's disease (BD) is a chronic inflammatory disorder characterized by vasculitis.
  • While venous thrombosis is common, cardiac and arterial involvement are increasingly recognized.
  • Multisystemic effects of BD impact various organs, including the cardiovascular system.

Purpose of the Study:

  • To review the cardiovascular manifestations of Behcet's disease.
  • To summarize the different types of cardiac lesions and arterial complications in BD.
  • To discuss current treatment strategies for cardiovascular involvement in BD.

Main Methods:

  • This is a review article.
  • Literature search on cardiovascular involvement in Behcet's disease.
  • Synthesis of information on manifestations and treatments.

Main Results:

  • Cardiac lesions in BD include pericarditis, endocarditis, intracardiac thrombosis, myocardial infarction, endomyocardial fibrosis, and myocardial aneurysm.
  • Arterial complications, particularly aneurysms and thromboses, pose significant treatment challenges due to bleeding risks.
  • Cardiovascular involvement significantly impacts the prognosis of Behcet's disease.

Conclusions:

  • Cardiovascular involvement is a critical aspect of Behcet's disease.
  • Effective management requires addressing vasculitis and specific cardiac/arterial lesions.
  • Oral anticoagulation, immunosuppressive therapy, and colchicine are key in managing cardiac involvement and improving prognosis.

Keywords:
Behcet's diseasecardiac manifestationstreatment

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