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Prognostic value of sST2 and galectin-3 for death relative to renal function in patients hospitalized for heart
Rongcheng Zhang, Yuhui Zhang, Tao An
12Division of Cardiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA.
Insights
Soluble ST2 (sST2) predicts death in heart failure (HF) patients regardless of kidney function. Galectin-3
Area of Science:
- Cardiology
- Biomarkers
- Renal Function
Background:
- Heart failure (HF) is a complex condition.
- Biomarkers play a crucial role in HF prognosis.
- Renal function impacts HF outcomes.
Purpose of the Study:
- To evaluate associations of soluble ST2 (sST2) and galectin-3 with mortality in HF patients.
- To assess the influence of renal function on these biomarker associations.
Main Methods:
- 1161 patients hospitalized for HF were enrolled.
- 1-year follow-up was conducted.
- Biomarker analysis included sST2 and galectin-3, with eGFR categorization.
Main Results:
- sST2 independently predicted death in HF patients across renal function categories (eGFR >60 and ≤60 ml/min/1.73 m²).
- Galectin-3's association with death lost statistical significance in patients with eGFR ≤60 ml/min/1.73 m² after adjusting for NT-proBNP.
- Renal function did not affect the prognostic value of sST2.
Conclusions:
- sST2 is a robust predictor of mortality in HF patients, independent of renal function.
- The prognostic utility of galectin-3 for death in HF is less reliable in patients with impaired renal function (eGFR <60 ml/min/1.73 m²).
- sST2 offers improved risk prediction beyond traditional factors in HF.
Aim:
To evaluate the associations of soluble ST2 (sST2) and galectin-3 with death relative to renal function in patients with heart failure (HF).
Methods:
Eleven-hundred-and-sixty-one patients hospitalized for HF with 1-year follow up were enrolled for biomarkers analysis.
Results:
Patients were divided into two groups based on eGFR of either > or ≤60 ml/min/1.73 m(2). sST2 was independently associated with death in both categories of renal function, while galectin-3 lost this significance after addition of NT-proBNP to the model of patients with eGFR ≤60 ml/min/1.73 m(2).
Conclusion:
In patients with HF, sST2 improved prediction for death beyond risk factors without being influenced by renal function, however, the prognostic value of galectin-3 is less clear below an eGFR of 60 ml/min/1.73 m(2).
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