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The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...

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Updated: Apr 12, 2026

Lensless Fluorescent Microscopy on a Chip

Lensless Fluorescent Microscopy on a Chip

Published on: August 17, 2011

Wide-field pathology imaging using on-chip microscopy.

Yibo Zhang¹, Alon Greenbaum, Wei Luo

¹Electrical Engineering Department, University of California, Los Angeles, CA, 90095, USA.

Virchows Archiv : an International Journal of Pathology

|May 20, 2015

Summary

This summary is machine-generated.

Lens-free microscopy offers a cost-effective, portable solution for high-throughput pathology slide imaging. This technology overcomes limitations of conventional light microscopes, benefiting resource-limited settings.

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Area of Science:

Biomedical Imaging
Pathology
Microscopy Technology

Background:

Conventional light microscopes have limitations including low throughput, high cost, bulkiness, and need for focus adjustment.
These drawbacks hinder the use of light microscopy in resource-limited environments.
Lens-free microscopy presents an alternative imaging approach.

Purpose of the Study:

To review the performance of a lens-free on-chip microscopy platform.
To demonstrate its capability for high-throughput pathology slide imaging.
To assess its potential in resource-poor settings.

Main Methods:

Utilized a lens-free on-chip microscopy platform for imaging.
Examined various biological samples, including blood smears and breast carcinoma.
Evaluated the platform's performance for pathology slide analysis.

Main Results:

The lens-free imaging platform demonstrated effective high-throughput slide imaging.
Successful imaging was achieved with diverse samples like normal and sickle-cell disease blood smears and human breast carcinoma.
The technology addresses limitations of conventional microscopy.

Conclusions:

Lens-free computational microscopy is a promising tool for high-throughput pathology.
It offers a viable solution for pathology needs, particularly in resource-limited settings.
The platform's portability and cost-effectiveness enhance its applicability.