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Updated: Apr 12, 2026

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
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[FGF/FGFR signalling: Implication in oncogenesis and perspectives]

Ronan Flippot1, Moumini Kone2, Nicolas Magné3

  • 1Gustave-Roussy, département d'innovations thérapeutiques essais précoces, 94800 Villejuif-Grand Paris, France.

Bulletin Du Cancer
|May 20, 2015
PubMed

Insights

Fibroblast growth factor (FGF)/FGF receptor (FGFR) pathway deregulation drives cancer progression. Targeted therapies show promise, but patient screening for FGFR alterations is crucial for effective treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Signal Transduction

Context:

  • Fibroblast growth factor (FGF) and FGF receptor (FGFR) signaling pathway dysregulation is implicated in numerous cancers.
  • This pathway's aberrant activation promotes key oncogenic mechanisms like proliferation, migration, and angiogenesis.
  • Understanding downstream signaling is vital for elucidating its oncogenic potential.

Purpose:

  • To detail the oncogenic mechanisms driven by FGF/FGFR signaling.
  • To explore the implications of FGF/FGFR pathway deregulation across various cancer types.
  • To highlight the role of FGF/FGFR signaling in melanoma, where it's a near-ubiquitous driver event.

Summary:

  • Deregulation of the FGF/FGFR pathway fuels cancer development by promoting proliferation, epithelial-mesenchymal transition, migration, and angiogenesis.
  • In melanoma, FGF/FGFR pathway alterations are driver events in approximately 90% of cases.
  • The FGF/FGFR pathway is a therapeutic target, with ongoing development of selective and multi-targeted agents.

Impact:

  • Targeted therapies for FGF/FGFR alterations are under development, showing promise in selected patient populations.
  • Recent clinical trials indicate that efficacy is linked to the presence of specific FGF/FGFR pathway alterations.
  • Patient stratification through careful screening is essential for evaluating the success of novel molecular therapies targeting this pathway.
Keywords:
AmplificationFGF receptorMelanomaMolecular targeted therapyMutationMélanomeThérapie moléculaire ciblée

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