Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

American Association of Hip and Knee Surgeons Position Statement on Opioid Use for the Treatment of Osteoarthritis of the Hip and Knee.

The Journal of arthroplasty·2026
Same author

Short Tibial Extensions Are Associated With Reduced Tibial Component Loosening for Primary, Cemented Total Knee Arthroplasty: A Systematic Review and Meta-Analysis.

The Journal of arthroplasty·2025
Same author

Increasing Use of Cemented Stems Is Associated With Reduced Early Fracture After Total Hip Arthroplasty: A Michigan Arthroplasty Registry Collaborative Quality Initiative Study.

The Journal of arthroplasty·2025
Same author

Durable reconstitution of sinonasal epithelium by transplant of CFTR gene corrected airway stem cells.

bioRxiv : the preprint server for biology·2025
Same author

Does a Provider Contact Wristband Reduce Emergency Department Visit Rates Following Hip or Knee Arthroplasty?

Arthroplasty today·2025
Same author

Single-cell, spatial, and fate-mapping analyses uncover niche dependent diversity of cochlear myeloid cells.

bioRxiv : the preprint server for biology·2024
Same journal

Intramedullary Clavicle Fixation Through a Posterolateral Portal: Description of a Novel Minimally Invasive Technique.

Journal of surgical orthopaedic advances·2026
Same journal

Incidence of Nonindicated and Inadequate Ankle Stress Views.

Journal of surgical orthopaedic advances·2026
Same journal

Glenohumeral Pathology Seen at the Time of Diagnostic Arthroscopy After Normal Magnetic Resonance Imaging.

Journal of surgical orthopaedic advances·2026
Same journal

Multivariate Analysis of Social Media Content by United States Orthopaedic Residency Program Directors.

Journal of surgical orthopaedic advances·2026
Same journal

Distal Radius Malunion Correction Without Bone Graft: A Systematic Review.

Journal of surgical orthopaedic advances·2026
Same journal

Sex Differences in the Relationship Between Hand and Leg Dominance and Knee Osteoarthritis Laterality.

Journal of surgical orthopaedic advances·2026
See all related articles

Related Experiment Video

Updated: Apr 12, 2026

Adjustable Stiffness, External Fixator for the Rat Femur Osteotomy and Segmental Bone Defect Models
10:09

Adjustable Stiffness, External Fixator for the Rat Femur Osteotomy and Segmental Bone Defect Models

Published on: October 9, 2014

23.5K

Reverse oblique end screws in nonlocking plates decrease construct strength in synthetic osteoporotic bone medium.

Paul M Charpentier1, Brian P Flanagan, Ajay K Srivastava

  • 1McLaren-Flint, Flint, Michigan.

Journal of Surgical Orthopaedic Advances
|May 20, 2015
PubMed
Summary
This summary is machine-generated.

Angling screws toward the fracture in dynamic compression plates significantly reduces fixation strength in osteoporotic bone. Reverse oblique screws are inferior, compromising fracture stability.

More Related Videos

A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions
06:41

A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions

Published on: March 22, 2018

8.8K
Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis
06:38

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis

Published on: October 12, 2016

10.6K

Related Experiment Videos

Last Updated: Apr 12, 2026

Adjustable Stiffness, External Fixator for the Rat Femur Osteotomy and Segmental Bone Defect Models
10:09

Adjustable Stiffness, External Fixator for the Rat Femur Osteotomy and Segmental Bone Defect Models

Published on: October 9, 2014

23.5K
A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions
06:41

A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions

Published on: March 22, 2018

8.8K
Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis
06:38

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis

Published on: October 12, 2016

10.6K

Area of Science:

  • Orthopedic surgery
  • Biomechanical engineering
  • Osteoporosis research

Background:

  • Fracture stability is a significant concern for patients with osteoporosis.
  • The end screw of non-locked plates experiences high loads and is prone to failure.
  • Current strategies involve angling screws away from the fracture to improve fixation.

Purpose of the Study:

  • To biomechanically evaluate the effect of angling the end screw toward the fracture.
  • To compare the fixation strength of reverse oblique, perpendicular, and oblique end screw orientations.
  • To assess the influence of plate length on construct stability in an osteoporotic bone model.

Main Methods:

  • Utilized a biomechanical testing model with osteoporotic bone.
  • Employed 3.5-mm dynamic compression plates of varying lengths (6-, 8-, and 12-hole).
  • Tested constructs in three-point bending with three end screw orientations: oblique, perpendicular, and reverse oblique.

Main Results:

  • Reverse oblique end screw constructs demonstrated significantly lower peak loads for screw fixation loss compared to other orientations.
  • Longer plate lengths (12-hole) exhibited significantly greater peak load, energy, and displacement than shorter plates (6- and 8-hole).
  • All tested screw orientations showed reduced performance with the reverse oblique configuration.

Conclusions:

  • Angling the end screw toward the fracture, specifically in a reverse oblique orientation, is biomechanically inferior.
  • The reverse oblique end screw orientation compromises fixation strength in osteoporotic bone models.
  • Surgeons should avoid reverse oblique end screw placement to enhance fracture fixation stability.