Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

1.3K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.3K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.6K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.6K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

87.5K
Overview
87.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antechodynamics and Antechokinetics: Dynamics and Kinetics of Antibiotic Resistance Biomolecules.

Biomolecules·2025
Same author

Simultaneous cochlear implantation and removal of acoustic neuroma: implications for hearing.

The Journal of laryngology and otology·2020
Same author

Myeloid-derived suppressor cells in lymphoma: The good, the bad and the ugly.

Blood reviews·2018
Same author

Diagnostic thresholds for free light chains in multiple myeloma depend on the assay used.

Leukemia·2017
Same author

The duration of asystolic ischemia determines the risk of graft failure after circulatory-dead donor kidney transplantation: A Eurotransplant cohort study.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2017
Same author

Prenatal fever and autism risk.

Molecular psychiatry·2017
Same journal

Alpha-Gal Syndrome: Unrecognized Risks of a Tick-Bite-Associated Allergy in Transplantation and Cellular Therapy.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Comment on "Role of social determinants and outcomes of patients with alcohol-associated liver disease referred for early liver transplantation: A multicenter analysis".

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Ebola disease caused by Bundibugyo virus, Democratic Republic of the Congo & Uganda.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Donor Acute Kidney Injury Is Not Associated With Inferior Outcomes After Simultaneous Pancreas-Kidney Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Human Biopsy-Defined IRI-Selective Reperfusion Signature Prioritizes Reperfusion-Timed MEK Inhibition After DCD Liver Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

OPERATIONAL TOLERANCE FOLLOWING INTESTINAL TRANSPLANTATION: A CASE REPORT WITH COMPREHENSIVE IMMUNE FOLLOW-UP FROM TRANSPLANT DAY TO THREE YEARS POST-IMMUNOSUPPRESSION WITHDRAWAL.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
See all related articles

Related Experiment Video

Updated: Apr 12, 2026

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment
08:25

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment

Published on: June 10, 2025

660

Macrochimerism in Intestinal Transplantation: Association With Lower Rejection Rates and Multivisceral Transplants,

J Zuber1, S Rosen1, B Shonts1

  • 1Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|May 20, 2015
PubMed
Summary
This summary is machine-generated.

Multivisceral transplantation frequently leads to T cell chimerism without graft-versus-host disease (GVHD). This blood chimerism may correlate with reduced organ transplant rejection rates, particularly in multivisceral transplant recipients.

Keywords:
flow cytometrylymphocyte biologymonitoring immunetrafficking

More Related Videos

Orthotopic Small Bowel Transplantation in Rats
09:16

Orthotopic Small Bowel Transplantation in Rats

Published on: November 6, 2012

14.8K
Orthotopic Hind Limb Transplantation in the Mouse
07:15

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

12.5K

Related Experiment Videos

Last Updated: Apr 12, 2026

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment
08:25

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment

Published on: June 10, 2025

660
Orthotopic Small Bowel Transplantation in Rats
09:16

Orthotopic Small Bowel Transplantation in Rats

Published on: November 6, 2012

14.8K
Orthotopic Hind Limb Transplantation in the Mouse
07:15

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

12.5K

Area of Science:

  • Transplantation immunology
  • Chimerism research
  • Organ transplant outcomes

Background:

  • Blood chimerism is infrequently observed post-transplant, often linked to graft-versus-host disease (GVHD).
  • The extent of chimerism may differ between isolated intestinal (iITx), multivisceral (MVTx), and isolated liver (iLTx) transplants.

Purpose of the Study:

  • To investigate the prevalence of multilineage blood chimerism in visceral transplant recipients.
  • To compare chimerism levels between MVTx, iITx, and iLTx recipients.
  • To explore the relationship between chimerism, GVHD, and organ rejection.

Main Methods:

  • Longitudinal prospective study of 9 iITx/MVTx recipients and 10 iLTx controls.
  • Flow cytometry used to assess multilineage blood chimerism up to one year post-transplant.
  • Analysis of chimerism in relation to GVHD, organ rejection, and donor-specific antibodies.

Main Results:

  • T cell chimerism was detected in 8/9 iITx/MVTx recipients, often without GVHD.
  • Chimerism was significantly lower in patients with moderate to severe rejection.
  • MVTx recipients showed higher T and B cell chimerism than iITx or iLTx recipients; myeloid chimerism was seen in iLTx and MVTx recipients.

Conclusions:

  • Frequent T cell chimerism occurs after visceral transplantation, independent of GVHD.
  • Higher chimerism in MVTx recipients suggests a potential protective effect against organ rejection.
  • Hepatic allografts may be necessary for myeloid lineage chimerism.