Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

IV Infusion to Oral Dosing: Conversion Methods

IV Infusion to Oral Dosing: Conversion Methods

The development of extended-release formulations has facilitated the transition from intravenous to oral medication, offering a more convenient and patient-friendly approach to drug administration. This transition, however, requires careful management to ensure that therapeutic drug levels are maintained, preserving efficacy and avoiding adverse effects. Understanding pharmacokinetic principles and dosage calculations is critical during this process.Pharmacokinetics of the...

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...

Routes of Drug Administration: Parenteral

Routes of Drug Administration: Parenteral

The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...

One-Compartment Model: IV Infusion

One-Compartment Model: IV Infusion

Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

"I Can't Poop": Medication-Induced Constipation.

Orthopedic nursing·2018

Same author

More New Medication Approvals.

Orthopedic nursing·2016

Same author

Catching Up on New Medications: New FDA Approvals.

Orthopedic nursing·2016

Same author

Glaucoma and glaucoma medications.

Orthopedic nursing·2012

Same author

One statin, two statins, three statins, more: similarities and differences of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.

Orthopedic nursing·2011

Same author

What's new? Medication changes 2008-2010.

Orthopedic nursing·2010

Search research articles

Related Experiment Video

Updated: Apr 12, 2026

An Open-Source Normothermic Perfusion System Designed for Research Scientists

An Open-Source Normothermic Perfusion System Designed for Research Scientists

Published on: July 18, 2025

Acetaminophen by infusion.

Beatrice B Turkoski¹

¹Beatrice B. Turkoski, PhD, RN, Graduate Faculty, Advanced Practice Nursing, Kent State University College of Nursing, Kent, OH.

Orthopedic Nursing

|May 20, 2015

Summary

Ofirmev, an injectable acetaminophen, offers versatile pain and fever relief for various patient groups. Understanding its uses and cautions is crucial for safe administration by nurses.

Area of Science:

Pharmacology
Anesthesiology
Critical Care Medicine

Background:

Acetaminophen is a widely used analgesic and antipyretic, commonly found in oral and rectal formulations.
Intravenous acetaminophen (Ofirmev) was approved in 2010, expanding its therapeutic applications.
Safe and effective use of intravenous acetaminophen requires informed healthcare professionals.

Purpose of the Study:

To discuss the approved uses of Ofirmev (intravenous acetaminophen).
To highlight the importance of understanding cautions associated with Ofirmev administration.
To inform nurses about the correct application of intravenous acetaminophen to prevent medication errors.

Main Methods:

Review of clinical guidelines and prescribing information for Ofirmev.

More Related Videos

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

A Model of Chronic Nutrient Infusion in the Rat

A Model of Chronic Nutrient Infusion in the Rat

Published on: August 14, 2013

Related Experiment Videos

Last Updated: Apr 12, 2026

An Open-Source Normothermic Perfusion System Designed for Research Scientists

An Open-Source Normothermic Perfusion System Designed for Research Scientists

Published on: July 18, 2025

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

A Model of Chronic Nutrient Infusion in the Rat

A Model of Chronic Nutrient Infusion in the Rat

Published on: August 14, 2013

Analysis of therapeutic indications for intravenous acetaminophen.

Discussion of potential adverse events and contraindications.

Main Results:

Ofirmev is indicated for mild to moderate pain, as an adjunct for severe pain with opioids, and for fever reduction in patients under 2 years old.
Intravenous acetaminophen offers a valuable alternative in various clinical settings.
Knowledge of Ofirmev's specific uses and cautions is essential for optimal patient outcomes.

Conclusions:

Intravenous acetaminophen (Ofirmev) provides a flexible treatment option for pain and fever.
Nurses play a critical role in ensuring the safe and effective use of Ofirmev.
Informed administration of Ofirmev can minimize medication misadventures and improve patient care.