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Updated: Apr 12, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
Published on: January 24, 2025
Lectin-gated, mesoporous, photofunctionalized glyconanoparticles for glutathione-responsive drug delivery
Juan Zhou1, Nanjing Hao, Thareendra De Zoyza
1Department of Chemistry, KTH - Royal Institute of Technology, Teknikringen 30, S-10044 Stockholm, Sweden. ramstrom@kth.se.
Abstract:
A stimuli-responsive drug delivery system based on fluorescent, lectin-gated, mesoporous glyconanoparticles has been developed and evaluated in normal- and cancer lung epithelial cells. The gating process proved efficient, exhibiting good sealing properties in the absence of the glutathione redox trigger, avoiding premature release in normal cells. In the presence of higher levels of glutathione in cancer cells, the lectin gate was rapidly opened and the anticancer drug released.
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