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Updated: Apr 12, 2026

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
Published on: November 25, 2015
Deactivation of signal amplification by reversible exchange catalysis, progress towards in vivo application
Ryan E Mewis1, Marianna Fekete, Gary G R Green
1Centre for Hyperpolarisation in Magnetic Resonance, University of York, Heslington, York YO10 5NY, UK. simon.duckett@york.ac.uk.
Abstract:
The catalyst which is used in the signal amplification by reversible exchange (SABRE) process facilitates substrate hyperpolarisation while acting to speed up the rate of relaxation. Consequently, the lifetime over which the hyperpolarised contrast agent is visible is drastically reduced. We show that the addition of a chelating ligand, such as bipyridine, rapidly deactivates the SABRE catalyst thereby lengthening the agent's relaxation times and improving the potential of SABRE for diagnostic MRI.
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