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Related Experiment Video

Updated: Apr 12, 2026

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

Published on: November 26, 2018

Monocyte trafficking across the vessel wall.

Teresa Gerhardt¹, Klaus Ley²

¹Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Cir, La Jolla, CA 92037, USA.

Cardiovascular Research

|May 21, 2015

Summary

Monocyte recruitment in inflammatory diseases involves complex cell trafficking across blood vessel walls. Recent research reveals new mediators and molecular players in this essential immune surveillance process.

Keywords:

Extravasation Monocyte migration Monocyte subsets

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Last Updated: Apr 12, 2026

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

Published on: November 26, 2018

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

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Laminar Flow-based Assays to Investigate Leukocyte Recruitment on Cultured Vascular Cells and Adherent Platelets

Laminar Flow-based Assays to Investigate Leukocyte Recruitment on Cultured Vascular Cells and Adherent Platelets

Published on: April 9, 2018

Area of Science:

Immunology
Cell Biology
Vascular Biology

Background:

Monocytes are crucial for immune surveillance and inflammatory responses in diseases like atherosclerosis.
Monocyte recruitment to injury sites involves a cascade of adhesion and migration events across the blood vessel wall.

Purpose of the Study:

To review conventional understanding and highlight novel findings in monocyte extravasation.
To discuss the roles of newly identified mediators, signaling pathways, and molecular structures in monocyte transmigration.

Main Methods:

Literature review and synthesis of recent research findings.
Analysis of the molecular mechanisms governing monocyte recruitment and endothelial transmigration.

Main Results:

New insights into monocyte differentiation and functional mediators have emerged.
The roles of various endothelial junctional and adhesion molecules (e.g., vascular endothelial-cadherin, ICAM-1, CD99, PECAM-1, CD155, CD146, ephrins) in monocyte extravasation are highlighted.

Conclusions:

Monocyte extravasation is a complex process involving multiple molecular interactions.
Understanding these novel aspects of monocyte trafficking is critical for developing therapies for immunoinflammatory diseases.