Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

681
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
681

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First divertor Thomson scattering measurements on MAST-U.

The Review of scientific instruments·2022
Same author

Pressure dependence of the metal-insulator transition in κ-(BEDT-TTF)<sub>2</sub>Hg(SCN)<sub>2</sub>Cl: optical and transport studies.

Journal of physics. Condensed matter : an Institute of Physics journal·2016
Same author

Cumulative incidence and risk factors for limber tail in the Dogslife labrador retriever cohort.

The Veterinary record·2016
Same author

Gender and motor competence affects perceived likelihood and importance of physical activity outcomes among 14 year olds.

Child: care, health and development·2015
Same author

Challenges of Pre- and Post-Test Counseling for Orthodox Jewish Individuals in the Premarital Phase.

Journal of genetic counseling·2015
Same author

Sexual selection on female ornaments in the sex-role-reversed Gulf pipefish (Syngnathus scovelli).

Journal of evolutionary biology·2014

Related Experiment Video

Updated: Apr 12, 2026

Mouse Models for Graft Arteriosclerosis
07:37

Mouse Models for Graft Arteriosclerosis

Published on: May 14, 2013

14.3K

Cardiac allograft pathology: A clinicopathologic correlation.

W Fraser Symmans1, H Nielsen1, R Dell2

  • 1Departments of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
|May 21, 2015
PubMed
Summary

Cardiac allograft pathology, including epicardial infiltrate and fibrosis, is linked to longer survival after heart transplantation. These findings aid in understanding rejection and improving patient outcomes.

More Related Videos

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis
07:05

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Published on: May 17, 2015

9.0K
Murine Cervical Aortic Transplantation Model using a Modified Non-Suture Cuff Technique
10:11

Murine Cervical Aortic Transplantation Model using a Modified Non-Suture Cuff Technique

Published on: November 2, 2019

6.8K

Related Experiment Videos

Last Updated: Apr 12, 2026

Mouse Models for Graft Arteriosclerosis
07:37

Mouse Models for Graft Arteriosclerosis

Published on: May 14, 2013

14.3K
Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis
07:05

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Published on: May 17, 2015

9.0K
Murine Cervical Aortic Transplantation Model using a Modified Non-Suture Cuff Technique
10:11

Murine Cervical Aortic Transplantation Model using a Modified Non-Suture Cuff Technique

Published on: November 2, 2019

6.8K

Area of Science:

  • Cardiology
  • Transplantation Immunology
  • Pathology

Background:

  • Cardiac allograft rejection is a major cause of graft failure.
  • Understanding the relationship between histological findings and clinical outcomes is crucial for improving patient survival.

Purpose of the Study:

  • To investigate the correlations between cardiac allograft pathology, clinical course, and endomyocardial biopsy results.
  • To identify pathological features associated with longer survival in heart transplant recipients.

Main Methods:

  • Histological assessment of 55 transplanted adult hearts (autopsies and retransplants).
  • Comparison of pathological changes in left and right ventricles and coronary arteries.
  • Statistical analysis including Fisher's exact test and survival curve analysis.

Main Results:

  • Pathological changes were similar in both ventricles, with equivalent transmural cellular infiltrate.
  • Epicardial infiltrate and fibrosis, along with epicardial-myocardial junction irregularity, were more frequent in longer-surviving allografts.
  • A history of rejection episodes correlated with left ventricular fibrosis; no significant correlation found between subendocardial/myocardial changes and coronary artery pathology.

Conclusions:

  • Specific pathological features, particularly epicardial changes, are associated with improved long-term outcomes in cardiac allografts.
  • Statistical modeling is effective for analyzing complex clinicopathological variables in transplantation.
  • Findings provide insights into the pathological basis of cardiac allograft survival.