Related Experiment Video
Updated: Apr 12, 2026
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Middle ear adenoma with neuroendocrine differentiation: relate of two cases and literature review
Aline Gomes Bittencourt1, Robinson Koji Tsuji2, Francisco Cabral3
1Otolaryngologist, Ph.D. Student. Department of Otolaryngology, University of São Paulo School of Medicine, São Paulo, Brazil.
Introduction:
Adenomas with neuroendocrine differentiation are defined as neuroendocrine neoplasms, and they are rarely found in the head and neck.
Objective:
To describe two cases of a middle ear adenoma with neuroendocrine differentiation, with a literature review.
Case Report:
Patient 1 was a 41-year-old woman who presented with a 3-year history of left aural fullness associated with ipsilateral "hammer beating" tinnitus. Patient 2 was a 41-year-old male who presented with unilateral conductive hearing loss.
Conclusion:
Adenoma with neuroendocrine differentiation of the middle ear is a rare entity, but it should be considered in patients with tinnitus, aural fullness, and a retrotympanic mass and remembered as a diferential diagnosis of tympanic paraganglioma.
