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Endothelium-derived essential signals involved in pancreas organogenesis

Dodanim Talavera-Adame1, Donald C Dafoe1

  • 1Dodanim Talavera-Adame, Donald C Dafoe, Comprehensive Transplant Center, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.

World Journal of Experimental Medicine
|May 21, 2015
PubMed

Insights

Endothelial cells (ECs) are crucial for pancreas development and function, influencing beta cell maturation and insulin secretion. Their role in diabetes and stem cell-derived beta cells is also highlighted.

Area of Science:

  • Developmental Biology
  • Endocrinology
  • Cell Biology

Background:

  • Endothelial cells (ECs) play a vital role in pancreas development, endocrine specification, and function.
  • ECs are implicated in the pathophysiology of type 1 and type 2 diabetes.
  • Aortic ECs provide essential factors for pancreas development, including maintaining key gene expression.

Purpose of the Study:

  • To review the role of ECs in pancreatic beta cell differentiation and maturation during embryogenesis.
  • To summarize current knowledge on endothelium involvement in deriving pancreatic beta cells from pluripotent stem cells.
  • To explore the cross-talk between ECs and endocrine cells in maintaining islet integrity and function.

Main Methods:

  • Literature review focusing on embryogenesis and stem cell research.
  • Analysis of gene expression and cell signaling pathways involving ECs and pancreatic cells.
  • Synthesis of data on EC-derived factors and their impact on beta cell development and function.

Main Results:

  • ECs are essential for pancreas differentiation and endocrine specification, maintaining key gene expression.
  • Immature beta cells recruit ECs via vascular endothelial growth factor, which then support insulin secretion.
  • Cross-talk between ECs and endocrine cells is critical for islet integrity and function throughout life.

Conclusions:

  • Endothelial cells are indispensable for pancreatic beta cell development, maturation, and function.
  • Understanding EC-beta cell interactions offers insights into diabetes and potential therapeutic strategies.
  • The review highlights the importance of endothelium in both natural development and in vitro generation of beta cells.

Keywords:
DifferentiationEndotheliumEndothelium-derived signalsOrganogenesisPancreas development

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