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Lung toxicity of biodegradable nanoparticles
Journal of Biomedical Nanotechnology
|May 21, 2015
Summary
Biodegradable nanoparticles show promise for lung drug delivery. Reviews indicate these nanomedicine carriers exhibit minimal to no toxicity in the respiratory tract.
Area of Science:
- Nanomedicine
- Toxicology
- Respiratory Medicine
Background:
- Biodegradable nanoparticles are promising for lung drug delivery.
- Concerns exist regarding nanoparticle toxicity to lung cells, including cytotoxic effects and inflammatory responses.
Purpose of the Study:
- To review the behavior and toxicological consequences of biodegradable nanoparticles in the respiratory tract.
- To assess nanomedicine safety for pulmonary administration.
Main Methods:
- Literature review of studies on biodegradable nanoparticles in the respiratory system.
- Analysis of toxicological data from in vitro, ex vivo, and in vivo models.
Main Results:
- Biodegradable nanoparticles interact with various parts of the respiratory tract.
- Evaluated toxicological consequences across different experimental models.
Conclusions:
- Current evidence suggests biodegradable nanoparticles exhibit no or only slight toxicity.
- Supports the potential of biodegradable nanoparticles as safe nanomedicine carriers for lung delivery.
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