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Premature birth as a risk factor for autism spectrum disorder

Rachel L Goldin1, Johnny L Matson1

  • 1a Department of Psychology , Louisiana State University , Baton Rouge , LA , USA.

Developmental Neurorehabilitation
|May 21, 2015
PubMed

Insights

Premature birth is linked to atypical development, not autism spectrum disorder (ASD). This finding offers new insights into developmental risks for children, aiding in early identification and intervention strategies for ASD.

Area of Science:

  • Developmental Pediatrics
  • Neurodevelopmental Disorders
  • Perinatal Medicine

Background:

  • Autism spectrum disorder (ASD) is a prevalent, lifelong neurodevelopmental condition with significant impact.
  • Identifying risk factors for ASD is crucial for early intervention and support.
  • Premature birth is increasingly recognized as a potential contributor to neurodevelopmental outcomes.

Purpose of the Study:

  • To investigate the association between premature birth and the development of autism spectrum disorder (ASD).
  • To compare the prevalence of premature births in children diagnosed with ASD versus those with atypical development.

Main Methods:

  • A cohort of 1655 at-risk children aged 17-37 months was analyzed.
  • Participants were categorized into two groups: those diagnosed with ASD (n=916) and those with atypical development only (n=739).

Main Results:

  • Premature births occurred nearly twice as frequently in the atypical development group compared to the ASD group.
  • This suggests a potential protective or differential association of prematurity with ASD versus other developmental delays.

Conclusions:

  • The findings indicate a complex relationship between premature birth and neurodevelopmental trajectories.
  • Further research is warranted to elucidate the mechanisms underlying these observations and their clinical implications.
Abstract

Keywords:
Autism spectrum disorderpremature birthrisk factors

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