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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Biological activity of natural sesquiterpenoids containing a gem-dimethylcyclopropane unit
María Jesús Durán-Peña1, José Manuel Botubol Ares, James R Hanson
1Department of Organic Chemistry, Faculty of Science, University of Cádiz, Polígono Río San Pedro s/n, 11510, Puerto Real, Cádiz, Spain. isidro.gonzalez@uca.es rosario.hernandez@uca.es.
Abstract:
The biological activities of aristolane, aromadendrane, ent-1,10-secoaromadendrane, 2,3-secoaromadendrane, ent-5,10-cycloaromadendrane, bicyclogermacrene, lepidozane, and maaliane terpenoids which contain the gem-dimethylcyclopropyl unit are described. Particular attention is given to their anti-viral, anti-microbial and cytotoxic activities. In the main text there are 119 references covering the literature from 1963-2014. The ESI contains tables listing 332 of these terpenoids, their occurrence and biological activity together with the related references.
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