Related Experiment Video
Updated: Apr 12, 2026
The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
Published on: February 3, 2012
Autoimmune hepatitis: an approach to disease understanding and management
Margaret Corrigan1, Gideon M Hirschfield2, Ye H Oo1
1NIHR Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, UK.
Introduction:
Autoimmune hepatitis is a chronic immune-mediated liver injury, frequently associated with progression to end-stage liver disease if untreated. Patients commonly present with hepatitis, positive immune serology, elevated immunoglobulins and compatible liver histology, in the absence of an alternative aetiology.
Sources Of Data:
Data for this review were obtained using PubMed.
Areas Of Agreement:
Disease usually responds to steroids and azathioprine, and appears to be a manifestation of autoimmune predisposition triggered in genetically susceptible individuals exposed to likely environmental challenges. We provide an up-to-date approach to disease understanding and management along with the clinical approach to diagnosis and current treatment suggestions.
Areas Of Controversy:
Controversies such as second line therapies and novel markers of disease activity are introduced.
Growing Points:
Increased understanding of the immunoregulatory mechanisms behind autoimmune hepatitis has led to opportunities for new therapies. These are developed including a discussion of timely research studies relevant to future therapies for patients.
More Related Videos
11:36Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
06:38An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Related Concept Videos
01:29Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
01:25Hepatitis
01:29Chronic Pancreatitis II: Collaborative Care
Assessment:
01:29Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
01:22Myocarditis IV: Nursing Management
01:27Gastritis-I: Introduction and Types
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...