Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccines01:21

Vaccines

53
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the...
53
Vaccinations01:51

Vaccinations

54.6K
Overview
54.6K
Symbiosis00:58

Symbiosis

38.8K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
38.8K
Cancer Vaccines01:30

Cancer Vaccines

1.4K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.4K
Diversity of Protists II01:27

Diversity of Protists II

2.2K
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
2.2K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.4K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacokinetics and pharmacodynamics of a long-acting monoclonal antibody against malaria in African adults.

The Journal of clinical investigation·2026
Same author

Identification of cross-stage, cross-species malaria CD8<sup>+</sup> T cell antigens.

Nature·2026
Same author

Targeting vaccine fusion proteins to APCs increases immunogenicity of adenoviral and mRNA-LNP vaccines.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

Addition of blood-stage antibody enhances anti-sporozoite antibody protection in a humanized mouse model of Plasmodium falciparum infection.

Cell reports·2026
Same author

Memory regulatory T cells reprogram into protective T<sub>FH</sub> cell-like effectors in recurrent malaria.

Nature immunology·2026
Same author

Integrated evaluation of antibody responses to mosquitoes and mosquito-borne pathogens using highly multiplexed serology.

Science advances·2026

Related Experiment Video

Updated: Apr 12, 2026

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes
08:20

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

Published on: August 17, 2022

2.8K

Malaria Vaccines: Moving Forward After Encouraging First Steps.

Tuan M Tran1, Silvia Portugal1, Simon J Draper2

  • 1Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Current Tropical Medicine Reports
|May 22, 2015
PubMed
Summary

Developing new malaria vaccines is crucial for reducing disease and aiding elimination efforts. While RTS,S/AS01 is a step forward, next-generation vaccines targeting multiple parasite stages are needed for eradication.

Keywords:
Clinical parasitologyCommentaryMalariaMalaria immunologyPlasmodium falciparumTravel medicineVaccinesVaccinology

More Related Videos

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
08:46

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

18.6K
High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
10:38

High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays

Published on: July 17, 2014

23.9K

Related Experiment Videos

Last Updated: Apr 12, 2026

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes
08:20

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

Published on: August 17, 2022

2.8K
Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
08:46

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

18.6K
High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
10:38

High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays

Published on: July 17, 2014

23.9K

Area of Science:

  • Immunology
  • Vaccinology
  • Infectious Diseases

Background:

  • Malaria remains a significant global health challenge, particularly in resource-limited endemic areas.
  • An effective malaria vaccine is essential for reducing disease burden and achieving elimination goals.
  • The first malaria vaccine, RTS,S/AS01, represents progress but presents challenges for evaluating subsequent vaccine candidates.

Purpose of the Study:

  • To review the current landscape of malaria vaccine development.
  • To discuss the challenges posed by partially effective vaccines like RTS,S/AS01 for future vaccine evaluation.
  • To explore next-generation malaria vaccine strategies for improved efficacy and eradication.

Main Methods:

  • Review of existing literature on malaria vaccine research and development.
  • Analysis of the efficacy and limitations of current and emerging vaccine candidates.
  • Discussion of immunological principles underlying different vaccine approaches.

Main Results:

  • RTS,S/AS01 is the first malaria vaccine poised for licensure, offering partial protection.
  • Whole-sporozoite vaccines show promise in inducing sterile immunity but may lack durability in endemic settings.
  • Multi-stage vaccines targeting different parasite forms (pre-erythrocytic, merozoite, sexual stages) are being explored.

Conclusions:

  • Achieving malaria elimination requires innovative vaccine strategies beyond current partially effective options.
  • Targeting multiple parasite life stages offers a promising path toward more durable protection and eradication.
  • Further research into multi-stage vaccines is critical for advancing malaria control and global eradication efforts.