Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serological evidence of high exposure to <i>Plasmodium falciparum</i> gameto-cytes in dry-Season in Kenieroba, Mali.

MalariaWorld journal·2026
Same author

Pharmacokinetics and pharmacodynamics of a long-acting monoclonal antibody against malaria in African adults.

The Journal of clinical investigation·2026
Same author

Integrated evaluation of antibody responses to mosquitoes and mosquito-borne pathogens using highly multiplexed serology.

Science advances·2026
Same author

Response by Vandenbriele et al to Letter Regarding Article, "Arterial Versus Mixed Venous Lactate Levels in 1526 Cardiac Intensive Care Patients".

Circulation. Heart failure·2026
Same author

Performance of prognostic scores for patients with cardiogenic shock supported With VA-ECMO.

Critical care (London, England)·2026
Same author

A Suite of Eight <i>Toxoplasma gondii</i> Effectors Cooperates to Activate the Non-canonical NF-κB Pathway.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jun 24, 2026

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
07:17

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

Memory regulatory T cells reprogram into protective TFH cell-like effectors in recurrent malaria.

Nana Appiah Essel Charles-Chess1,2, Anthony A Ruberto2,3,4, Carson Bowers2

  • 1Department of Cellular Biology, University of Georgia, Athens, GA, USA.

Nature Immunology
|June 22, 2026
PubMed
Summary

Memory regulatory T (Treg) cells switch from suppressing to protecting during recurrent malaria infections. This plasticity enhances antibody production and controls Plasmodium parasite levels, revealing a novel immune response mechanism.

More Related Videos

Accessing Early Differentiation of Virus-Specific Follicular Helper CD4+ T Cell in Acute LCMV-Infected Mice
05:03

Accessing Early Differentiation of Virus-Specific Follicular Helper CD4+ T Cell in Acute LCMV-Infected Mice

Published on: April 26, 2024

Related Experiment Videos

Last Updated: Jun 24, 2026

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
07:17

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

Accessing Early Differentiation of Virus-Specific Follicular Helper CD4+ T Cell in Acute LCMV-Infected Mice
05:03

Accessing Early Differentiation of Virus-Specific Follicular Helper CD4+ T Cell in Acute LCMV-Infected Mice

Published on: April 26, 2024

Area of Science:

  • Immunology
  • Infectious Diseases
  • Malariology

Background:

  • Recurrent Plasmodium infections are common in endemic areas, but the role of regulatory T (Treg) cells is unclear.
  • During primary Plasmodium infection, Treg cells suppress protective immunity and germinal center (GC) reactions, hindering parasite control.
  • Memory Treg (mTreg) cells, persisting after initial infection, may have different functions upon reinfection.

Purpose of the Study:

  • To investigate the role and function of mTreg cells during recurrent Plasmodium infections.
  • To understand the plasticity and adaptive potential of mTreg cells in the context of malaria reinfection.
  • To elucidate the mechanisms by which mTreg cells influence adaptive immunity and parasite control.

Main Methods:

  • Longitudinal studies in human and mouse models of recurrent Plasmodium infection.
  • Analysis of mTreg cell expansion, epigenetic reprogramming, and differentiation.
  • Assessment of GC reactions, antibody generation, and Plasmodium control.

Main Results:

  • mTreg cells expand antigen-specifically and undergo epigenetic reprogramming during reinfection.
  • mTreg cells transition from immunosuppressive FOXP3+ cells to follicular T helper (Tfh)-like BCL6+ effectors.
  • These mTreg-derived Tfh-like cells enhance GC responses and Plasmodium-specific antibody production, improving parasite control.
  • Blocking mTreg to Tfh cell differentiation abrogated protective immunity.

Conclusions:

  • mTreg cells exhibit adaptive plasticity, switching function from immunosuppressive to protective during recurrent malaria.
  • This functional switch enhances adaptive immunity, facilitating Plasmodium control through improved antibody responses.
  • Findings reveal a novel mechanism of immune regulation and protection in the context of repeated parasitic infections.