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Polarization and Characterization of M1 and M2 Human Monocyte-Derived Macrophages on Implant Surfaces

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Neovascularization And Macrophage Behavior Under The Influence Of Androgens In The Tissue-Implant Response.

K R Butler¹, Hamed Benghuzzi, Michelle Tucci

¹University of Mississippi Medical Center.

Biomedical Sciences Instrumentation

|May 22, 2015

Summary

Macrophages significantly correlate with blood vessel formation in calcium phosphate (TCP) ceramic drug delivery systems. This relationship is particularly strong when androgens are present, impacting biocompatibility.

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Area of Science:

Biomaterials Science
Immunology
Vascular Biology

Background:

Implantable ceramic materials, such as calcium phosphate (TCP), are crucial for drug delivery systems.
Macrophage presence and neovascularization are key factors influencing the biocompatibility and function of these implants.

Purpose of the Study:

To investigate the correlation between macrophage populations and neovascularization within the fibrous capsule of TCP ceramic drug delivery systems.
To define the relationship and correlation of macrophages and vascularity in response to different androgen-loaded TCP ceramics.

Main Methods:

Surgical implantation of TCP bioceramics (control, testosterone, dihydrotestosterone, androstenedione loaded) in sixteen animals.
Histological analysis (H&E staining) of fibrous tissue capsules at 90 days post-implantation.
Microscopic determination of macrophage populations and neovascularity using ImagePro digital analysis software.

Main Results:

A significant positive correlation was observed between macrophage counts and vascularity (p<0.05) in androgen-loaded TCP groups (II, III, IV).
The control group (Group I) did not show a statistically significant correlation between macrophages and vascularity.
Exogenous androgens demonstrated varying effects on both vascularity and macrophage infiltration.

Conclusions:

Macrophage presence is directly associated with neovascularization in the fibrous capsule surrounding TCP ceramic implants.
This association is significantly enhanced in the presence of exogenous androgens, suggesting a role in modulating the host response to drug delivery systems.