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Updated: Apr 12, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Gold and silver catalysis: from organic transformation to bioconjugation
Vanessa Kar-Yan Lo1, Anna On-Yee Chan, Chi-Ming Che
1State Key Laboratory of Synthetic Chemistry and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China. cmche@hku.hk.
Abstract:
This review focuses on gold (including gold(I) and gold(III) complexes, and gold nanoparticles) and silver(I) catalysis, including aerobic oxidation, activation of C-H bonds and activation of C-C multiple bonds, and their applications in the modification of biomolecules, including oligosaccharides, peptides and polypeptides, reported since the year 2000. Because of the high carbophilicity of gold and silver compounds, gold or silver-catalysed/mediated organic transformations feature high functional group tolerance, excellent regio-, diastereo- or enantioselectivity and/or high product turnover numbers under mild reaction conditions.
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