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Updated: Apr 12, 2026

Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example
Published on: November 18, 2015
Monitoring organic reactions by UF-NMR spectroscopy
Antonio Herrera1,2, Encarnación Fernández-Valle1, Roberto Martínez-Álvarez2
1CAI-RMN, Universidad Complutense de Madrid, Madrid, Spain.
Abstract:
Standard 2D NMR experiments suffer from the many t1 increments needed for spectra with sufficient digital resolution in the indirect dimension. Despite the different methodological approaches to overcome this problem, these increments have prevented studies of fast reactions. The development of ultrafast NMR (UF-NMR) has decisively speeded up the time scale of standard NMR to allow the study of organic reactions as they happen in real time to reveal mechanistic details. This mini-review summarizes the results achieved in monitoring organic reactions through this exciting technique.
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